An intact urease assembly pathway is required to compete with NikR for nickel ions in Helicobacter pylori.
نویسندگان
چکیده
We examined the effects of urease and hydrogenase assembly gene deletions on NikR activation in H. pylori strains 26695 and G27. The loss of any component of urease assembly increased NikR activity under Ni2+-limiting conditions, as measured by reduced transcript levels and 63Ni accumulation. Additionally, SlyD functioned in urease assembly in strain 26695.
منابع مشابه
NikR mediates nickel-responsive transcriptional induction of urease expression in Helicobacter pylori.
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ورودعنوان ژورنال:
- Journal of bacteriology
دوره 191 7 شماره
صفحات -
تاریخ انتشار 2009